Article

Reproducibility of behavioral phenotypes in mouse models - a short history with critical and practical notes

Author(s) / Creator(s)

Voikar, Vootele

Other kind(s) of contributor

University of Helsinki

Abstract / Description

Progress in pre-clinical research is built on reproducible findings, yet reproducibility has different dimensions and even meanings. Indeed, the terms reproducibility, repeatability, and replicability are often used interchangeably, although each has a distinct definition. Moreover, reproducibility can be discussed at the level of methods, analysis, results, or conclusions. Despite these differences in definitions and dimensions, the main aim for an individual research group is the ability to develop new studies and hypotheses based on firm and reliable findings from previous experiments. In practice this wish is often difficult to accomplish. In this review, issues affecting reproducibility in the field of mouse behavioral phenotyping are discussed.

Keyword(s)

behavioral phenotyping mouse reproducibility core facility

Persistent Identifier

Date of first publication

2020-08-13

Journal title

Journal for Reproducibility in Neuroscience

Volume

1

Article number

1375

Publisher

PsychArchives

Publication status

publishedVersion

Review status

notReviewed

Is version of

Citation

Voikar, V. (2020). Reproducibility of behavioral phenotypes in mouse models - a short history with critical and practical notes. Journal for Reproducibility in Neuroscience, 1, 1375. https://doi.org/10.31885/jrn.1.2020.1375
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  • Author(s) / Creator(s)
    Voikar, Vootele
  • Other kind(s) of contributor
    University of Helsinki
  • PsychArchives acquisition timestamp
    2022-03-09T12:53:01Z
  • Made available on
    2022-03-09T12:53:01Z
  • Date of first publication
    2020-08-13
  • Abstract / Description
    Progress in pre-clinical research is built on reproducible findings, yet reproducibility has different dimensions and even meanings. Indeed, the terms reproducibility, repeatability, and replicability are often used interchangeably, although each has a distinct definition. Moreover, reproducibility can be discussed at the level of methods, analysis, results, or conclusions. Despite these differences in definitions and dimensions, the main aim for an individual research group is the ability to develop new studies and hypotheses based on firm and reliable findings from previous experiments. In practice this wish is often difficult to accomplish. In this review, issues affecting reproducibility in the field of mouse behavioral phenotyping are discussed.
    en
  • Publication status
    publishedVersion
  • Review status
    notReviewed
  • Citation
    Voikar, V. (2020). Reproducibility of behavioral phenotypes in mouse models - a short history with critical and practical notes. Journal for Reproducibility in Neuroscience, 1, 1375. https://doi.org/10.31885/jrn.1.2020.1375
  • ISSN
    2670-3815
  • Persistent Identifier
    https://hdl.handle.net/20.500.12034/5000
  • Persistent Identifier
    https://doi.org/10.23668/psycharchives.5601
  • Language of content
    eng
  • Publisher
    PsychArchives
  • Is version of
    https://doi.org/10.31885/jrn.1.2020.1375
  • Keyword(s)
    behavioral phenotyping
    en
  • Keyword(s)
    mouse
    en
  • Keyword(s)
    reproducibility
    en
  • Keyword(s)
    core facility
    en
  • Dewey Decimal Classification number(s)
    150
  • Title
    Reproducibility of behavioral phenotypes in mouse models - a short history with critical and practical notes
    en
  • DRO type
    article
  • Article number
    1375
  • Journal title
    Journal for Reproducibility in Neuroscience
    en
  • Volume
    1